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. 2020 Feb 13;21(4):1761–1770. doi: 10.3892/mmr.2020.10987

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Effects of MALAT1 inhibition on ox-LDL-stimulated macrophages are partly reversed by suppressing miR-17-5p expression. After co-transfection of NC siRNA or MALAT1 siRNA, and NC inhibitor or miR-17-5p inhibitor for 24 h, macrophages were stimulated with 50 mg/ml ox-LDL for 48 h. (A) Level of T-CHO in THP-1 macrophages. (B) Western blot analysis, and (C) quantification of the expression levels of ApoE and ABCA1. Data are presented as the mean ± SD. *P<0.05, ***P<0.001 vs. NC siRNA group. ^&P<0.05, ^&&P<0.01, ^&&&P<0.001 vs. MALAT1 siRNA + NC inhibitor. NC, negative control; miR, microRNA; ox-LDL, oxidized low-density lipoprotein; ABCA1, ATP-binding cassette transporter A1; MALAT1, metastasis associated lung adenocarcinoma transcript 1; siRNA, small interfering RNA; ApoE apolipoprotein E; T-CHO, total cholesterol.