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In response to DNA damage p53 gets phosphorylated at serine-15 in a phosho-ATM/ATR dependent manner. RUNX1 and RUNX3 play similar roles in promoting p53 acetylation and recruiting it to gene promoters of downstream target genes involved in DNA repair, cell cycle arrest and apoptosis. Association of RUNX2 with HDAC6 dampens acetylation to repress apoptosis and maintain cell cycle progression.
