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RUNX1-inhibition treatment induces p53. Induced p53 directly binds to CBFB promoter and stimulates its transcription and translation, which in turn acts as a platform for the stabilization of RUNX1, thereby creating the compensative RUNX1-p53-CBFB feedback loop. Modified from the article of Morita et al. (2017c) (Sci. Rep. 7, 16604) in accordance with the Creative Commons Attribution 4.0 International (CC BY 4.0) license.
