Fig. 3. Schematic abstract showing that RUNX1 enhances leukemia cell engraftment in the vascular niche possibly through modulating E-selectin expressions.

Left: E-Selectin keeps AML cells in the bone marrow (BM) niche where chemodrug concentration is lower. Right: RUNX1 inhibition esposes AML cells to higher concenyrationof chemodrug in periferal blood (PB). Modified from the article of Morita et al. (2018) (Blood Adv. 2, 509-515) with original copyright holder's permission.