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. 2020 Feb 27;11:74. doi: 10.3389/fimmu.2020.00074

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Copyright © 2020 Quaglia, Dellepiane, Guglielmetti, Merlotti, Castellano and Cantaluppi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of Extracellular Vescicles (EVs) in alloantigen presentation to T lymphocytes. (A) Classical direct and indirect presentation; (B) “semi-direct” presentation trough cross-dressing of recipient APC with graft-derived EVs.