Table 3.
Main miRNAs involved in renal protection from IRI.
| miRNA | Parental cell | Mechanism of action | References |
|---|---|---|---|
| miR-125a | Adipose tissue-MSC | Increases endothelial cell angiogenesis | (172) |
| miR-29b | MSC | Inhibits epithelial mesenchymal transition of rat renal tubule epithelial cells | (173) |
| miR-21 | MSC | Inhibits renal tubule epithelial cells apoptosis and DC maturation | (174) |
| miR-let7c | MSC | Inhibits renal fibrosis | (175) |
| mi-R 30 | Wharton Jelly-MSC | Inhibits renal tubule epithelial cells mitochondrial fission | (176) |
| miR-199a-5p | Bone marrow-MSC | Alleviate endoplasmic reticulum stress at reperfusion | (177) |
| miR-486-5p | Endothelial cell forming colonies | Inhibits endothelial cell apoptosis and endothelial-mesenchymal transition | (178, 179) |
| miR-218 | Renal artery progenitor cell | Increases endothelial cell migration | (180) |
| miR-126 miR-296 | Endothelial progenitor cell | Increases endothelial cell angiogenesis | (181) |