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. 2020 Feb 27;11:328. doi: 10.3389/fimmu.2020.00328

Figure 1.

Figure 1

Increased microbial translocation and reduced in vivo influenza vaccine antibody response in P2KO vs. WT mice. (A) Microbial translocation in serum was measured by ELISA for LPS in young and old WT and P2KO mice (4 mice/group). Mean comparisons between groups were performed by two-way ANOVA. *p < 0.05, **p < 0.01. (B) To measure the influenza vaccine response, mice were immunized intramuscularly with the influenza vaccine. Serum response to the vaccine was evaluated at day 28 post vaccination by ELISA. (C) Influenza vaccine-specific IgA responses measured by ELISA at day 28 post vaccination. (D) Total serum IgG measured by ELISA. Mean comparisons between groups were performed by two-way ANOVA followed by Bonferroni's multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001. (E) Correlation of microbial translocation and influenza vaccine response. Pearson's r and p-values are at the bottom of the figure.