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(A–C) BrdU immunostaining on cross sections of wild type mouse hippocampus at 3, 6, and 12 months of age. (A′–C′) BrdU immunostaining on cross sections of APP/PS1dE9 mouse hippocampus at 3, 6, and 12 months of age. (D) Quantification of total BrdU positive cells per mouse hippocampus. Proliferation reduces significantly at 12 months of age in APP/PS1dE9 mouse. n = 4 animals. Scale bars: 100 μm.
