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. 2020 Feb 26;8:114. doi: 10.3389/fcell.2020.00114

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Copyright © 2020 Mashkaryan, Siddiqui, Popova, Cosacak, Bhattarai, Brandt, Govindarajan, Petzold, Reinhardt, Dahl, Lefort and Kizil.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Immunostaining for GFAP (red) and GFP after transplantation of astroglia transduced with Lv-UbiC:GFP into wild type mouse cortex. (B) Immunostaining for OLIG2 (red) and GFP after transplantation of astroglia transduced with Lv-UbiC:GFP into wild type mouse cortex. (C) Immunostaining for GFP after transplantation of astroglia transduced with Lv-UbiC:GFP into adult mouse cortex shows neuronal morphologies. (D) Immunostaining for GFP after transplantation of astroglia transduced with Lv-UbiC:STAT6VT-GFP into adult mouse cortex. (E) Immunostaining for OLIG2 (red) and GFP after transplantation of astroglia transduced with Lv-UbiC:STAT6VT-GFP into wild type mouse cortex. (F) Immunostaining for GFAP (red) and GFP after transplantation of astroglia transduced with Lv-UbiC:STAT6VT-GFP into wild type mouse cortex. (G) Immunostaining for GFAP (orange) and GFP after transplantation of astroglia transduced with Lv-UbiC:GFP into APP/PS1dE9 adult mouse cortex. (H) Immunostaining for GFAP (orange) and GFP after transplantation of astroglia transduced with Lv-UbiC:STAT6VT-GFP into APP/PS1dE9 adult mouse cortex. n = 3 animals. Schematic information on injection locations presented in the insets. Scale bars: 50 μm.