Figure 1.

Upregulation of HIF-1α increases secretion of VEGF and bFGF in HCT-116 cells. (A) Western blot of HIF-1α levels in HCT-116 cells. (B) HIF-1α mRNA expression levels were increased under hypoxic conditions and in HIF-1α overexpression vector-transfected cells. (C) VEGF expression and (D) bFGF expression in the supernatant of HCT-116 cells were analyzed. **P<0.01 vs. the control, ^▲▲P<0.01 vs. the vector control. HIF-1α, hypoxia inducible factor-1α; VEGF, vascular endothelial growth factor; bFGF, basic fibroblast growth factor.