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. 2020 Feb 10;43(4):1125–1132. doi: 10.3892/or.2020.7496

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Piwil2-iCSC-Exo (200 µg/ml) enhance FB proliferation, migration and invasion. (A) The optimization experiments. (B) Proliferation of FBs after 0, 24, 48 and 72 h of incubation with Piwil2-iCSC-Exo. (C) Wound healing assays; representative images after 0, 12 and 24 h (×100 magnification). (D) Invasion assay; representative images (×100 magnification). At least 3 independent experiments were performed. Results were considered statistically significant at P<0.05 (**P<0.01, ***P<0.001 vs. control group; ^##P<0.01, ^###P<0.001 vs. PBS group). One-way ANOVA and the LSD post hoc test were selected for analysis. FBs, fibroblasts; Piwil2-iCSC-Exo, exosomes derived from Piwil2-induced cancer stem cells.