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. 2020 Mar 5;10:4123. doi: 10.1038/s41598-020-60275-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of PDE4 inhibitor and anti-IL17a antibody on Th1/Th17-incorporated 3D skin. Immunofluorescence staining of (a) K16 (red) and (b) CD3 (green) in Th1/Th17-bearing HSCs without treatment (left panel), with 2.5 μM PDE4 inhibitor treatment (middle panel), and 1 μg/ml anti-IL17a antibody treatment (left panel). (c) Relative cytokine secretion of IFNγ, IL-17a, IL-1b, IL-6, and IL-8 from Th1/Th17-bearing HSCs after PDE4 inhibitor or anti-IL17a antibody treatment on day 2.