Table 2.
Details of radiotherapy and clinical course in hepatocellular carcinoma patients with tumour thrombus.
| Patient | A | B | C | D | E | F |
|---|---|---|---|---|---|---|
| SBRT technique | ||||||
| Gat | Gat | Gat | Gat | Sup | Sup | |
| Dose-Volume Histogram | ||||||
| Normal liver (Liver-PTV) | ||||||
| Volume (cc) | 1070 | 1589 | 1375 | 1096 | 863 | 1288 |
| Mean (Gy) | 8.2 | 9.6 | 8.7 | 5.0 | 5.9 | 6.6 |
| Estimated remnant liver | ||||||
| Volume (cc) | 871 | 365 | 387 | 970 | 640 | 995 |
| Mean (Gy) | 6.0 | 10.6 | 5.6 | 3.0 | 3.2 | 4.9 |
| PTV | ||||||
| Volume (cc) | 20.0 | 45.0 | 53.9 | 16.9 | 28.1 | 79.8 |
| Dmax of organs at risk | ||||||
| Spinal cord (Gy) | 4.7 | 10.5 | 16.3 | 2.5 | 4.7 | 12.4 |
| Stomach (Gy) | 24.8 | 5.1 | 20.7 | 19.3 | 12.3 | 21.5 |
| Duodenum (Gy) | 6.0 | 3.5 | 23.4 | 10.6 | 11.5 | 13.3 |
| Bowel (Gy) | 11.1 | 1.2 | 10.6 | 11.7 | 0.6 | 14.3 |
| Period from SBRT to operation (days) | ||||||
| 17 | 6 | 7 | 10 | 9 | 12 | |
| Pathology | ||||||
| Differentiation | P | M | W-P | W | P | P |
| Necrotic change | 100% | 30% | 100% | 30% | 30% | 100% |
| Degeneration | − | + | + | |||
| Clinical Course | ||||||
| Intrahepatic recurrence | NED | Rec | NED | NED | NED | NED |
| Extrahepatic recurrence | NED | Rec | NED | NED | NED | NED |
Abbreviations: SBRT: stereotactic body radiotherapy; Gat: respiratory-gated SBRT, Sup: respiratory-suppressed SBRT, PTV: planning target volume, Dmax: maximum dose. P: Poorly differentiated, M: moderately differentiated; W: well differentiated; NED: no evidence of disease; Rec: recurrence.