Table 3.
Literature reports of preoperative radiotherapy.
| Author | N | Necrosis | Preoperative Treatment | Period from RT to surgery | RR | Acute AEs* | RILD |
|---|---|---|---|---|---|---|---|
| Wada16 | 2 | 60–100% | 3D-CRT 60 Gy / 6 fr. and 39 Gy / 13 fr. | 3–4 weeks | NA | 0% | 0% |
| Kamiyama17 | 15 | Viable-100% | 3D-CRT 30–36 Gy / 10–12 fr. | 2 weeks | NA | 6.7% | 0% |
| Choi24 | 16 | 30–100% | TACE + 3D-CRT 30–68 Gy | 4.7 months | NA | NA | NA |
| Yeh23 | 12 | NA | IMRT 60 Gy / 30 fr. | 1.2–5 months | 11.3% | 0% | NA |
| This study | 6 | 30–100% | SBRT (for PVTT only) 48 Gy / 4 fr. | 2 weeks (6-17 days) | 75% | 0% | 0% |
Abbreviations: RR: resection rate; HR: hepatic resection NA: not assessed; RILD: radiation-induced liver disease; SBRT: stereotactic body radiotherapy; IMRT: intensity-modulated radiotherapy; TACE: transarterial chemoembolization; 3D-CRT: three-dimensional conformal radiotherapy; RT: radiotherapy;
*worse than grade 2.