Figure 2.

Increase in free MG blood levels and tumor volume (± SD) following PROb cell transplantation. Subcutaneous injection of PROb cells into syngeneic BD-IX rats allows the establishment of progressively growing tumors. A significant 7-fold increase (P=0.003) in MG blood level was observed. Free MG blood levels increased from 0.095±0.021 µM at T0, to 0.703±0.178 µM at 9 weeks after transplantation.At each time point, the measured tumor volume and the MG blood level obtained at time T were compared with those obtained previously, i.e. T9 vs. T6, T6 vs. T4, T4 vs. T3, T3 vs. T2 and T2 vs. T0. Horizontal bars represent the significant statistical results obtained using Friedman's test with Nemenyi post-hoc comparisons. ^*P<0.05, ^**P<0.01, ^***P<0.001, ^****P<0.0001, as indicated. PROb cells, tumorigenic clone cells; MG, methylglyoxal.