Figure 3.

Lack of change in free MG blood levels and tumor volume (± SD) after REGb cell transplantation. Subcutaneous injection of REGb cells into syngeneic BD-IX rats resulted in complete rejection of measurable tumors at 4 weeks after transplantation. The levels of free MG did not differ significantly from normal T0 values during the entire experimental study period (P=0.63). At each time point, the measured tumor volume and the MG blood level obtained at time T were compared with those obtained previously, i.e., T9 vs. T6, T6 vs. T4, T4 vs. T3, T3 vs. T2 and T2 vs. T0. Horizontal bars represent the significant statistical results obtained using the Friedman's test with Nemenyi post-hoc comparisons. ^*P<0.05, ^**P<0.01, ^****P<0.0001, as indicated. MG, methylglyoxal; REGb cells, non-tumorigenic clone cells.