Table I.
Association of the clinicopathological features and Ki67 expression in all involved CRC cases.
| N | Ki67+ | Ki67++ | Ki67+++ | Ki67++++ | P-value | |
|---|---|---|---|---|---|---|
| Sex, n (%) | 0.684 | |||||
| Male | 550 | 61 (46.6) | 141 (49.5) | 202 (50.9) | 146 (52.7) | |
| Female | 540 | 70 (53.4) | 144 (50.5) | 195 (49.1) | 131 (47.3) | |
| Mean age (years) | 1,090 | 61.64±15.80 | 62.79±14.33 | 62.21±14.28 | 62.07±14.31 | 0.880 |
| ASA stage, n (%) | 0.860 | |||||
| I | 797 | 94 (71.8) | 212 (74.4) | 293 (73.8) | 198 (71.3) | |
| II | 264 | 33 (25.2) | 64 (22.5) | 93 (23.4) | 74 (26.7) | |
| III | 29 | 4 (3.1) | 9 (3.2) | 11 (2.8) | 5 (1.8) | |
| Location, n (%) | 0.439 | |||||
| Ileocecum | 73 | 11 (8.4) | 20 (7.0) | 24 (6.0) | 18 (6.5) | |
| Right colon | 95 | 4 (3.1) | 31 (10.9) | 41 (10.3) | 19 (6.9) | |
| Transverse colon | 174 | 25 (19.1) | 42 (14.7) | 60 (15.1) | 47 (17.0) | |
| Left colon | 206 | 24 (18.3) | 57 (20.0) | 75 (18.9) | 50 (18.1) | |
| Sigmoid colon | 108 | 16 (12.2) | 20 (7.0) | 40 (10.1) | 32 (11.6) | |
| Rectum | 434 | 51 (38.9) | 115 (40.4) | 157 (39.5) | 111 (40.1) | |
| Surgical method, n (%) | 0.768 | |||||
| RHC | 207 | 21 (16.0) | 58 (20.4) | 80 (20.2) | 48 (17.3) | |
| LHC | 431 | 55 (42.0) | 108 (37.9) | 155 (39.0) | 113 (40.8) | |
| HO | 24 | 3 (2.3) | 7 (2.5) | 6 (1.5) | 8 (2.9) | |
| AR | 327 | 43 (32.8) | 91 (31.9) | 112 (28.2) | 81 (29.2) | |
| APR | 101 | 9 (6.9) | 21 (7.4) | 44 (11.1) | 27 (9.7) | |
| Operation time (min) | 1,090 | 153.6±34.8 | 151.2±38.6 | 155.0±33.2 | 154.1±33.2 | 0.568 |
| Invasive depth, n (%) | <0.001a | |||||
| Tis and T1 | 127 | 24 (18.3) | 53 (18.6) | 31 (7.8) | 19 (6.9) | |
| T2 | 210 | 5 (3.8) | 66 (23.2) | 112 (28.2) | 27 (9.7) | |
| T3 | 421 | 78 (59.5) | 92 (32.3) | 132 (33.2) | 119 (43.0) | |
| T4 | 332 | 24 (18.3) | 74 (6.0) | 122 (30.7) | 112 (40.4) | |
| Differentiation, n (%) | <0.001a | |||||
| Well | 194 | 58 (44.3) | 97 (34.0) | 30 (7.6) | 9 (3.2) | |
| Moderate | 696 | 69 (52.7) | 177 (62.1) | 282 (71.0) | 168 (60.6) | |
| Poor or undifferentiation | 200 | 4 (3.1) | 11 (3.9) | 85 (21.4) | 100 (36.1) | |
| Tumor size (cm) | 1,090 | 3.58±1.1 | 3.38±1.2 | 3.74±0.9 | 3.79±0.9 | <0.001a |
| AJCC-8, n (%) | 0.003a | |||||
| 0 | 16 | 5 (3.8) | 11 (3.9) | 0 (0) | 0 (0) | |
| I | 131 | 17 (13.0) | 85 (29.8) | 28 (7.1) | 1 (0.4) | |
| II | 225 | 93 (71.0) | 112 (39.3) | 12 (3.0) | 8 (2.9) | |
| III | 663 | 14 (10.7) | 75 (26.3) | 323 (81.4) | 25 (90.6) | |
| IV | 55 | 2 (1.5) | 2 (0.7) | 34 (8.6) | 17 (6.1) | |
| No. of lymph nodes harvested | 1,090 | 14.04±1.9 | 14.17±1.8 | 14.25±1.8 | 14.19±1.9 | 0.727 |
| No of positive lymph nodes | 1,090 | 0.25±0.9 | 0.61±1.4 | 2.45±2.2 | 2.86±2.5 | <0.001a |
| Complications | 0.587 | |||||
| Yes | 104 | 13 (9.9) | 28 (9.8) | 32 (8.1) | 31 (11.2) | |
| No | 986 | 118 (90.1) | 257 (90.2) | 365 (91.9) | 246 (88.8) | |
| Chemotherapy, n (%) | 0.005a | |||||
| Yes | 895 | 107 (81.7) | 189 (66.3) | 343 (86.4) | 256 (92.4) | |
| No | 195 | 24 (18.3) | 96 (33.7) | 54 (13.6) | 21 (7.6) |
a
P<0.05, statistical difference. Data for age, operation time, tumor size, no. of lymph harvested and no. of positive lymph nodes are expressed as mean ± standard deviation. CRC, colorectal cancer; AJCC-8, American Joint Committee on Cancer 8 edition; ASS, American Society of Anesthesiologists. Surgical method: RHC, right hemicolectomy; LHC, left hemicolectomy; HO, Hartmann; AR, anterior rectal resection APR, anterior rectal perineal resection.