Table 2.
Comparison of RORγt positivity and clinical and pathological features of aggressiveness of differentiated thyroid carcinomas.
| Clinical feature | Estimation of percentage of tumor cells expressing nuclear RORγt | p-valuea | |||
|---|---|---|---|---|---|
| 0% | 1–10% | 11–50% | > 50% | ||
| Gender | |||||
| Male | 1 (10.0) | 2 (20.0) | 1 (10.0) | 6 (60.0) | 0.961 |
| Female | 6 (13.0) | 12 (26.1) | 4 (8.7) | 24 (52.2) | |
| Age at diagnosis | |||||
| 45 yrs or less | 3 (11.1) | 9 (33.3) | 2 (7.4) | 13 (48.1) | 0.583 |
| More 45 yrs | 4 (13.8) | 5 (17.2) | 3 (10.3) | 17 (58.6) | |
| Histologic types | |||||
| Classic PTC | 2 (11.1) | 8 (44.4) | 0 (0.0) | 8 (44.4) | 0.381* |
| FV-PTC | 1 (6.7) | 4 (26.7) | 2 (13.3) | 8 (53.3) | 0.280** |
| TC-PTC | 1 (12.5) | 0 (0.0) | 2 (25.0) | 5 (62.5) | 0.592*** |
| PD-PTC | 1 (14.3) | 1 (14.3) | 0 (0.0) | 5 (71.4) | |
| FTC | 2 (25.0) | 1 (12.5) | 1 (12.5) | 4 (50.0) | |
| Multifocality | |||||
| Unifocal | 2 (7.1) | 7 (25.0) | 4 (14.3) | 15 (53.6) | 0.379 |
| Multifocal | 5 (17.9) | 7 (25.0) | 1 (3.6) | 15 (53.6) | |
| Concurrent CLT | |||||
| Absent | 7 (16.7) | 10 (23.8) | 4 (9.5) | 21 (50.0) | 0.408 |
| Present | 0 (0.0) | 4 (28.6) | 1 (7.1) | 9 (64.3) | |
| Tumor size, Mean ± SD | 4.6 ± 2.9 | 2.8 ± 1.5 | 3.7 ± 1.9 | 2.8 ± 2.4 | 0.185 |
| LN metastasis at diagnosis | |||||
| Absent | 3 (9.1) | 6 (18.2) | 2 (6.1) | 22 (66.7) | 0.163 |
| Present | 4 (17.4) | 8 (34.8) | 3 (13.0) | 8 (34.8) | |
| Distant metastasis at diagnosis | |||||
| Absent | 3 (6.4) | 12 (25.5) | 4 (8.5) | 28 (59.6) | 0.013 |
| Present | 4 (44.5) | 2 (22.2) | 1 (11.1) | 2 (22.2) | |
| RAI doses, Mean ± SD | 492.8 ± 386.7 | 247.6 ± 173.1 | 254.0 ± 127.8 | 230.0 ± 261.5 | 0.039 |
Abbreviations: SD, standard deviation; CLT, chronic lymphocytic thyroiditis; PTC, papillary thyroid carcinoma; FV-PTC, follicular variant of PTC; TC-PTC, tall cell variant of PTC; PD-PTC, poorly differentiated, PTC; FTC, follicular thyroid carcinoma; RAI, radioactive iodine therapy cumulative doses.
Note: aThe p-value expressed was obtained when the comparison was done considering the four different categories separated and not combined. *Comparison considering all different histologic subtypes (5 categories); **comparison considering different subtype of PTC (4 categories); ***comparison considering PTC versus FTC.