Table 3.
Comparison of IL-1β positivity and clinical and pathological features of aggressiveness of differentiated thyroid carcinomas.
| Clinical feature | Estimation of positivity for IL-1β | p-value | |
|---|---|---|---|
| Negative | Positive | ||
| Gender | |||
| Male | 4 (40.0) | 6 (60.0) | 0.897 |
| Female | 19 (42.2) | 26 (57.8) | |
| Age at diagnosis | |||
| 45 yrs or less | 11 (42.3) | 15 (57.7) | 0.944 |
| more 45 yrs | 12 (41.4) | 17 (58.6) | |
| Histologic types | |||
| Classic PTC | 9 (50.0) | 9 (50.0) | 0.278* |
| FV-PTC | 5 (33.3) | 10 (66.7) | 0.268** |
| TC-PTC | 2 (25.0) | 6 (75.0) | 0.297*** |
| PD-PTC | 5 (71.4) | 2 (28.6) | |
| FTC | 2 (25.0) | 6 (75.0) | |
| Multifocality | |||
| Unifocal | 11 (39.3) | 17 (60.7) | 0.698 |
| Multifocal | 12 (44.4) | 15 (55.6) | |
| Concurrent CLT | |||
| Absent | 14 (34.1) | 27 (65.9) | 0.048 |
| Present | 9 (64.3) | 5 (35.7%) | |
| Tumor size, Mean ± SD | 2.4 ± 2.0 | 3.7 ± 2.3 | 0.032 |
| LN metastasis at diagnosis | |||
| Absent | 15 (45.5) | 18 (54.5) | 0.503 |
| Present | 8 (36.4) | 14 (63.6) | |
| Distant metastasis at diagnosis | |||
| Absent | 22 (46.8) | 25 (53.2) | 0.041 |
| Present | 1 (12.5) | 7 (87.5) | |
| RAI doses, Mean ± SD | 178.2 ± 206.0 | 332.4 ± 282.8 | 0.004 |
Abbreviations: SD, standard deviation; CLT, chronic lymphocytic thyroiditis; PTC, papillary thyroid carcinoma; FV-PTC, follicular variant of PTC; TC-PTC, tall cell variant of PTC; PD-PTC, poorly differentiated, PTC; FTC, follicular thyroid carcinoma; RAI, radioactive iodine therapy cumulative doses.
Note: *Comparison considering all different histologic subtypes (5 categories); **comparison considering different subtype of PTC (4 categories); ***comparison considering PTC versus FTC.