Table 4.
Comparison of IL-23 positivity and clinical and pathological features of aggressiveness of differentiated thyroid carcinomas.
| Clinical Feature | Estimation of positivity for IL-23 | ||
|---|---|---|---|
| Negative | Positive | p-value | |
| Gender | |||
| Male | 3 (30.0) | 7 (70.0) | 0.978 |
| Female | 14 (30.4) | 32 (69.6) | |
| Age at diagnosis | |||
| 45 yrs or less | 9 (33.3) | 18 (66.7) | 0.640 |
| more 45 yrs | 8 (27.6) | 21 (72.4) | |
| Histologic types | |||
| Classic PTC | 8 (44.4) | 10 (55.6) | 0.019* |
| FV-PTC | 2 (13.3) | 13 (86.7) | 0.020** |
| TC-PTC | 1 (12.5) | 7 (87.5) | 0.235*** |
| PD-PTC | 5 (71.4) | 2 (28.6) | |
| FTC | 1 (12.5) | 7 (87.5) | |
| Multifocality | |||
| Unifocal | 7 (25.0) | 21 (75.0) | 0.383 |
| Multifocal | 10 (35.7) | 18 (64.3) | |
| Concurrent CLT | |||
| Absent | 11 (26.2) | 31 (73.8) | 0.240 |
| Present | 6 (42.9) | 8 (57.1) | |
| Tumor size, Mean ± SD | 2.2 ± 2.2 | 3.6 ± 2.2 | 0.009 |
| LN metastasis at diagnosis | |||
| Absent | 10 (30.3) | 23 (69.7) | 0.949 |
| Present | 7 (30.4) | 16 (69.6) | |
| Distant metastasis at diagnosis | |||
| Absent | 17 (36.2) | 30 (63.8) | 0.031 |
| Present | 0 (0.0) | 9 (100.0) | |
| RAI doses, Mean ± SD | 158.8 ± 153.3 | 317.6 ± 283.9 | 0.037 |
Abbreviations: SD, standard deviation; CLT, chronic lymphocytic thyroiditis; PTC, papillary thyroid carcinoma; FV-PTC, follicular variant of PTC; TC-PTC, tall cell variant of PTC; PD-PTC, poorly differentiated, PTC; FTC, follicular thyroid carcinoma; RAI, radioactive iodine therapy cumulative doses.
Note: *comparison considering all different histologic subtypes (5 categories); **comparison considering different subtype of PTC (4 categories); ***comparison considering PTC versus FTC.