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. 2020 Mar 5;10:4080. doi: 10.1038/s41598-020-60998-0

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© The Author(s) 2020, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional analysis of consistent heterogeneity changes. (a) Distribution of consistent heterogeneity increase for the significantly enriched KEGG pathways, in development and aging. x- and y-axes show the number of datasets with a consistent increase and the density for each significant pathway, respectively. The dashed red line shows x = 9.5, which is the middle point for 19 datasets, representing no tendency to increase or decrease. Values higher than 9.5, shown with red color, indicate an increase in heterogeneity while values lower than 9.5, shown with blue color, indicate a decrease in heterogeneity and the darkness shows the consistency in change across datasets. (b) The longevity regulating pathway (KEGG Pathway ID: hsa04211), exemplifying the distribution of the genes (circles), their heterogeneity across datasets (color – the same color scheme as panel (a)), and their relationship in the pathway (edges). More detailed schemes for all significant pathways with the gene names are given as SI.