Hazout 2003 8 IU.
Methods | Randomisation: stated as randomised. Allocation concealment: unclear. Blinding: double. Intention to treat analysis: not performed. Power calculation: not performed. Study setting: single centre ‐ Paris, France. Withdrawals: none. Cancelled cycles: <10%. |
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Participants | Number of women n = 35 (12 growth hormone four IU, 11 growth hormone eight IU, 12 placebo). Inclusion criteria: women were <39 years old with normal hormonal status and history of oocyte dysmorphia defined by <50% of abnormal oocyte at previous attempts. |
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Interventions | Intervention: four or eight IU sub cutaneous. Induction protocol: unclear. Dose of human chorionic gonadotropin: 1000 IU IM when at least two follicles were >16mm in diameter. | |
Outcomes | Pregnancy rate. | |
Notes | Same trial as Hazout 2003. but refers to women randomised to growth hormone 8 IU treatment arm. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Adequate sequence generation? | Unclear risk | Stated as randomised |
Allocation concealment? | Unclear risk | Not stated within the text |
Blinding? All outcomes | Low risk | Double blinded |
Free of selective reporting? | Low risk | There is no indication the study has reported outcomes selectively |
Free of other bias? | High risk | No adverse effects reported |