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. 2010 Jan 20;2010(1):CD000099. doi: 10.1002/14651858.CD000099.pub3

Kueuk 2008.

Methods Randomisation: computer generated randomisation. Allocation concealment: sealed envelopes. Blinding: triple. Intention to treat analysis: not performed. Power calculation: not performed. Study setting: single centre ‐ Bursa, Turkey. Withdrawals: none. Cancelled cycles: <10%.
Participants Number of women n= 61 (31 growth hormone, 30 placebo).
Inclusion criteria: women who responded poorly to high dose gonadotrophin treatment in their first cycles in the same centre. Cause of subfertility: Not stated.
Interventions Intervention: growth hormone 12IU sub cutaneous from day 21 of preceding cycle along with GnRHa, until the day of human chorionic gonadotropin. Treatment Protocol: Long GnRHa/FSH/hMG protocol used. Dose of human chorionic gonadotropin: 10000 IU when sat least 1 follicle was > 17mm in diameter.
Outcomes Clinical pregnancy.
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Adequate sequence generation? Low risk Computer generated randomisation
Allocation concealment? Unclear risk Sealed envelopes. No details as to whether opaque
Blinding? 
 All outcomes Low risk Triple blinded
Free of selective reporting? Low risk There is no indication the study has reported outcomes selectively
Free of other bias? High risk No adverse effects reported