Kueuk 2008.
Methods | Randomisation: computer generated randomisation. Allocation concealment: sealed envelopes. Blinding: triple. Intention to treat analysis: not performed. Power calculation: not performed. Study setting: single centre ‐ Bursa, Turkey. Withdrawals: none. Cancelled cycles: <10%. | |
Participants | Number of women n= 61 (31 growth hormone, 30 placebo). Inclusion criteria: women who responded poorly to high dose gonadotrophin treatment in their first cycles in the same centre. Cause of subfertility: Not stated. |
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Interventions | Intervention: growth hormone 12IU sub cutaneous from day 21 of preceding cycle along with GnRHa, until the day of human chorionic gonadotropin. Treatment Protocol: Long GnRHa/FSH/hMG protocol used. Dose of human chorionic gonadotropin: 10000 IU when sat least 1 follicle was > 17mm in diameter. | |
Outcomes | Clinical pregnancy. | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Adequate sequence generation? | Low risk | Computer generated randomisation |
Allocation concealment? | Unclear risk | Sealed envelopes. No details as to whether opaque |
Blinding? All outcomes | Low risk | Triple blinded |
Free of selective reporting? | Low risk | There is no indication the study has reported outcomes selectively |
Free of other bias? | High risk | No adverse effects reported |