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. 2010 Jan 20;2010(1):CD000099. doi: 10.1002/14651858.CD000099.pub3

Zhuang 1994.

Methods Randomisation: stated as randomised, method unclear.
Allocation concealment: unclear of method
Blinding: Outcome assessors were blind to treatment allocation.
Study Design: Parallel.
Study Setting: unclear.
Analysis; Power calculation done.
Withdrawals; none. Cancelled Cycles; none.
Participants Number of women randomised: n=27 (12 growth hormone, 15 control). Definition of poor response: not provided
Inclusion Criteria: previous sub‐optimal response to hyperstimulation cycles in IVF. Exclusion Criteria: Cause of subfertility: tubal factor or unexplained. Age: growth hormone 33.2 +/‐3.9, Placebo 32.3 +/‐3.9.
Interventions Intervention: growth hormone 12 IU IM on alternate days. Treatment Protocol: GnRH‐a (Buserelin nasal spray) from day 21 of previous menstrual cycle to day of human chorionic gonadotropin injection (do not know dose of GnRH‐a) 
 2 IU hMG given on alternate days for 12 days (at same time as growth hormone). Dose of human chorionic gonadotropin: 10000 iu.
Outcomes Live birth rate and pregnancy rate.
Notes Some information will have been stated in the trial but was not translated. The sections that were translated were kindly done so by Teresa Gu.
Risk of bias
Bias Authors' judgement Support for judgement
Adequate sequence generation? Unclear risk Stated as randomised
Allocation concealment? Unclear risk Not stated within the text
Blinding? 
 All outcomes Low risk Single
Free of selective reporting? Low risk There is no indication the study has reported outcomes selectively
Free of other bias? High risk No details of adverse effects reported

BA: Buserelin Acetate 
 E2: Oestrogen 
 Only outcomes relevant to the review were stated in the table of included studies 
 GnRH‐a: Gonadotrophin releasing hormone agonist