Zhuang 1994.
Methods | Randomisation: stated as randomised, method unclear. Allocation concealment: unclear of method Blinding: Outcome assessors were blind to treatment allocation. Study Design: Parallel. Study Setting: unclear. Analysis; Power calculation done. Withdrawals; none. Cancelled Cycles; none. |
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Participants | Number of women randomised: n=27 (12 growth hormone, 15 control). Definition of poor response: not provided Inclusion Criteria: previous sub‐optimal response to hyperstimulation cycles in IVF. Exclusion Criteria: Cause of subfertility: tubal factor or unexplained. Age: growth hormone 33.2 +/‐3.9, Placebo 32.3 +/‐3.9. |
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Interventions | Intervention: growth hormone 12 IU IM on alternate days. Treatment Protocol: GnRH‐a (Buserelin nasal spray) from day 21 of previous menstrual cycle to day of human chorionic gonadotropin injection (do not know dose of GnRH‐a) 2 IU hMG given on alternate days for 12 days (at same time as growth hormone). Dose of human chorionic gonadotropin: 10000 iu. | |
Outcomes | Live birth rate and pregnancy rate. | |
Notes | Some information will have been stated in the trial but was not translated. The sections that were translated were kindly done so by Teresa Gu. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Adequate sequence generation? | Unclear risk | Stated as randomised |
Allocation concealment? | Unclear risk | Not stated within the text |
Blinding? All outcomes | Low risk | Single |
Free of selective reporting? | Low risk | There is no indication the study has reported outcomes selectively |
Free of other bias? | High risk | No details of adverse effects reported |
BA: Buserelin Acetate E2: Oestrogen Only outcomes relevant to the review were stated in the table of included studies GnRH‐a: Gonadotrophin releasing hormone agonist