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. 2020 Mar 5;9(3):31. doi: 10.1038/s41389-020-0216-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a The schematic diagram of the 5T33MMvt-KaLwRij model. b Kaplan–Meier analyses of overall survival of different experimental groups. c The concentrations of Ig light-chain proteins in the serum of different groups were determined with ELISA (*p < 0.05, **p < 0.01, ***p < 0.001). d B220⁺CD138⁺IgM⁺ plasmablast cells from mice bone marrow were selected with flow cytometry, and the percentages of plasmablast cells were calculated in the respective groups (*p < 0.05, **p < 0.01, ***p < 0.001). e Extramedullary myeloma tissues removed from 5T33MMvt-KaLwRij mice were subjected to immunostaining for CD138 (green) and Xbp1s (orange). f The model of our hypothesis in this work.