Table 1. Overview of the studied traits.
| Trait | Cluster 1 n = 4,405 |
Cluster 2 n = 4,496 |
Cluster 3 n = 4,401 |
Cluster 4 n = 3,490 |
Total n = 16,792 |
|---|---|---|---|---|---|
| Age (yr), mean (SD) | 48.8 (11.0) | 47.9 (11.2) | 48.3 (11.1) | 48.2 (10.9) | 48.3 (11.0) |
| Male, n (%) | 2251 (51.1) | 2248 (50.0) | 2121 (48.2) | 1786 (51.2) | 8406 (50.1) |
| BMI, mean (SD) | 24.4 (2.92) | 21.6 (2.54) | 23.3 (2.60) | 27.1 (3.16) | 23.9 (3.39) |
| Total cholesterol (mg/dL), mean (SD) | 185 (31.8) | 183 (30.7) | 199 (32.7) | 203 (33.8) | 192 (33.3) |
| HDL (mg/dL), mean (SD) | 48.7 (9.92) | 62.3 (12.4) | 55.4 (12.1) | 46.8 (9.54) | 53.7 (12.7) |
| LDL (mg/dL), mean (SD) | 118 (28.2) | 107 (26.7) | 127 (29.3) | 133 (30.2) | 121 (30.1) |
| Triglyceride (mg/dL), mean (SD) | 113 (56.1) | 64.6 (24.3) | 99.3 (45.7) | 152 (68.4) | 104 (58.4) |
| Fasting Glucose (mg/dL), mean (SD) | 92.2 (8.04) | 90.1 (7.56) | 91.6 (7.23) | 97.5 (10.7) | 92.6 (8.75) |
| HbA1c (%) | 5.61 (0.365) | 5.46 (0.334) | 5.50 (0.328) | 5.84 (0.450) | 5.59 (0.394) |
| Uric acid (mg/dL), mean (SD) | 5.44 (1.31) | 4.94 (1.19) | 5.77 (1.38) | 6.37 (1.44) | 5.59 (1.42) |
| eGFR (mL/min), mean (SD) | 106 (13.2) | 106 (12.5) | 99.2 (14.3) | 102 (14.0) | 103 (13.8) |
| Platelet (1000/uL), mean (SD) | 255 (56.9) | 222 (48.4) | 226 (47.9) | 253 (56.5) | 238 (54.5) |
| Systolic blood pressure (mmHg), mean (SD) | 117 (15.6) | 111 (15.3) | 115 (16.2) | 124 (16.5) | 116 (16.5) |
| Diastolic blood pressure (mmHg), mean (SD) | 72.3 (9.96) | 68.9 (9.68) | 72.1 (10.4) | 77.7 (10.6) | 72.4 (10.6) |
| Total bilirubin (mg/dL), mean (SD) | 0.56 (0.21) | 0.75 (0.25) | 0.74 (0.24) | 0.62 (0.23) | 0.66 (0.24) |
| Dyslipidemia, n (%) | 242 (5.5) | 123 (2.7) | 237 (5.4) | 339 (9.7) | 941 (5.6) |
| Hypertension, n (%) | 450 (10.2) | 195 (4.3) | 385 (8.7) | 596 (17.1) | 1626 (9.7) |
| Diabetes (%), n (%) | 113 (2.6) | 49 (1.1) | 42 (1.0) | 155 (4.4) | 359 (2.1) |
Cluster 1: Subjects with moderate prevalence of dyslipidemia and moderately high prevalence of hypertension and diabetes; Cluster 2: Relatively healthy subjects; Cluster 3: Subjects with moderate prevalence of dyslipidemia, hypertension and diabetes; Cluster 4: Subjects with high prevalence of dyslipidemia, hypertension and diabetes