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. 2020 Feb 24;16(2):e1008083. doi: 10.1371/journal.ppat.1008083

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© 2020 Chu et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — A. Uptake of fluorescent virions for IgG1 and IgG3 hinge variant forms of VRC01 and the CH65 control antibody (assessed in duplicate, bar indicates mean). B. Neutralization profiles of IgG1 hinge variants of VRC01 (left) and IgG3 hinge variants of 447-52D (right) on selected sensitive viruses. Titrations were performed in duplicate. Gray region indicates the limit of detection. C-D. Antibody dependent complement deposition (ADCD) (C) and antibody dependent neutrophil phagocytosis (ADNP) (D) activity of VRC01 (left) and 447-52D (right) hinge variants in IgG1 (top) and IgG3 (bottom) forms of gp120 MN antigen-coated beads. Data represent means of duplicates. AU: arbitrary units.