Table 1. Recommendations for outcomes and outcome measures to be included in clinical trials.

Outcome domain	Patient-preferred outcome	Outcome (3,4,6)	Outcome measure
Recurrence	Relapse	Recurrence	Follow-up duration of 180 days (6 months)
Daily activities	Social life	QoL	QoL questionnaire, e.g. the DLQI [43] or the CLIQ [44] before treatment and at 6 months follow-up
	Work
	Good fitness level
Pain	Very strong pain
	Itching, stinging or tingling
Scar formation	Absence as proxy for cure
		Degree of functional and aesthetic impairment and/or prevention of scarring	Scar assessment, e.g. Vancouver Scar Scale [45] at 6 months follow-up

Patient-preferred outcomes were mapped to outcome designations as listed in the reviews conducted by the Cochrane Collaboration [3,4,6] and outcome measures (measurement instruments) are suggested. Limitations of the DLQI [43] are discussed in the text.