Table 1.
Demographics and clinical variables for the FTD patient groups and controls, together with basal forebrain volumes. Values denote means (standard deviation) or n (%). Mean volumes in bold denote significant p-values in comparison to controls once adjusting for multiple comparisons.
| Groups | n | Gender, male | Age at scan (years) | Disease duration (years) | Basal forebrain volume as % of TIV | p-value | |
|---|---|---|---|---|---|---|---|
| Controls | 83 | 45 (54%) | 63.4 (10.8) | – | 0.071 (0.007) | – | |
| Clinical | bvFTD | 148 | 103 (70%) | 61.5 (8.2) | 5.1 3.3) | 0.066 (0.008) | <0.0005 |
| nfvPPA | 103 | 49 (48%) | 68.4 (8.5) | 4.3 (2.2) | 0.068 (0.007) | <0.0005 | |
| svPPA | 82 | 46 (56%) | 63.8 (7.3) | 4.8 (2.5) | 0.065 (0.007) | <0.0005 | |
| PPA-NOS | 14 | 10 (71%) | 63.9 (6.2) | 3.3 (1.7) | 0.067 (0.006) | 0.005 | |
| FTD–MND | 9 | 5 (56%) | 65.3 (4.1) | 4.5 (2.4) | 0.066 (0.007) | 0.010 | |
| Genetic | C9orf72 | 26 | 17 (65%) | 61.6 (7.0) | 5.5 (3.3) | 0.072 (0.007) | 0.857 |
| GRN | 15 | 7 (47%) | 62.6 (6.7) | 2.9 (2.7) | 0.069 (0.006) | 0.107 | |
| MAPT | 24 | 15 (63%) | 55.4 (7.0) | 5.7 (3.2) | 0.059 (0.008) | <0.0005 | |
| Pathological | TDP-43 | 35 | 21 (60%) | 63.3 (7.9) | 4.3 (2.5) | 0.068 (0.006) | 0.003 |
| TDP-A | 12 | 6 (50%) | 61.6 (8.2) | 3.1 (1.6) | 0.069 (0.005) | 0.133 | |
| TDP-B | 2 | 1 (50%) | 55.0 (9.4) | 5.0 (3.7) | 0.077 (0.009) | 0.403 | |
| TDP-C | 21 | 14 (67%) | 65.1 (7.3) | 4.9 (2.7) | 0.066 (0.005) | 0.001 | |
| Tau | 28 | 21 (72%) | 61.8 (9.7) | 4.7 (2.3) | 0.065 (0.007) | <0.0005 | |
| Pick's disease | 11 | 8 (73%) | 61.3 (2.5) | 4.2 (2.0) | 0.063 (0.006) | <0.0005 | |
| FTDP-17 | 6 | 4 (67%) | 52.4 (6.2) | 5.8 (3.1) | 0.060 (0.009) | <0.0005 | |
| CBD | 7 | 5 (71%) | 59.5 (9.0) | 4.5 (0.9) | 0.071 (0.006) | 0.609 | |
| PSP | 4 | 4 (100%) | 76.9 (7.3) | 5.1 (3.9) | 0.064 (0.003) | 0.030 | |
| FUS | 3 | 2 (67%) | 43.9 (13.6) | 3.3 (2.1) | 0.066 (0.008) | 0.172 | |