Table 2.
Basal forebrain volumetric comparisons between controls and the different clinical, genetic, and pathological groups. Volumes are adjusted for age, scanner type and gender, as well as disease duration for within patient group comparisons.
| Clinical | FTD–MND | bvFTD | nfvPPA | PPA-NOS | svPPA | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| % difference | p-value | % difference | p-value | % difference | p-value | % difference | p-value | % difference | p-value | |
| Controls | 9% | 0.010 | 9% | <0.0005 | 5% | <0.0005 | 8% | 0.005 | 10% | <0.0005 |
| FTD–MND | 0% | 0.911 | −4% | 0.293 | −1% | 0.847 | 1% | 0.807 | ||
| bvFTD | −4% | 0.016 | −1% | 0.876 | 1% | 0.373 | ||||
| nfvPPA | 3% | 0.325 | 5% | 0.003 | ||||||
| PPA-NOS | 2% | 0.565 | ||||||||
| Genetic | C9orf72 | MAPT | GRN | |||||||
| % difference | p-value | % difference | p-value | % difference | p-value | |||||
| Controls | 0% | 0.857 | 18% | <0.0005 | 4% | 0.107 | ||||
| C9orf72 | 17% | <0.0005 | 3% | 0.210 | ||||||
| MAPT | 14% | <0.0005 | ||||||||
| Pathological | Tau | FUS | TDP-43 | |||||||
| % difference | p-value | % difference | p-value | % difference | p- value | |||||
| Controls | 10% | <0.0005 | 10% | 0.172 | 6% | 0.003 | ||||
| Tau | −2% | 0.730 | 5% | 0.092 | ||||||
| FUS | 3% | 0.729 | ||||||||