. Author manuscript; available in PMC: 2020 Mar 5.

Published in final edited form as: Int Arch Allergy Immunol. 2016 Sep 20;170(4):211–233. doi: 10.1159/000448756

Table 1. Model peptides used to study APL function.

Peptide	MHC	Role described or differential T cell function elicited by APLs	References
Murine (in vitro)
Hb(64 – 76)	I-E^k	IL-4 production and T cell-B cell collaboration (as assessed by B cell proliferation and Ig production) by Th2 clones; cytolytic activity, upregulation of CD25 and of LFA-1 and increased cell volume by Th1 clones; anergy in Th1 and Th2 clones	1, 10, 28, 37
PCC(88 – 104)	I-E^k	Inhibition of IL-2 production by Th1 clones; upregulation of CD25 and increased cell volume; negative selection of DP thymocytes	12, 13
OVA(257 – 264)	K^b	TCR antagonism of cytolysis, cytokine production, Ca²⁺ flux and serine esterase release in Th1 clones; induction of positive selection of thymocytes	4, 6, 48
LCMV GP(33 – 41)	H-2D^b	Induction of positive selection of thymocytes and cytotoxic T cell memory	49, 197
MCC(88 – 103)	H-2E^k	Inhibition of IL-2 production, upregulation of CD25 and increased cell volume; negative selection of DP thymocytes	13
huColIV	I-A^s, I-A^b	Differential IFN-γ and IL-4 production and T cell-B cell collaboration (as assessed by Ig production)	11

Human (in vitro)
HA(307 – 319)	HLA-DR1	TCR antagonism causing reduced proliferation of Th1 clones	3
TT(830 – 843)	HLA-DR1	TCR antagonism causing reduced proliferation of Th1 clones	3
HA(307 – 319)	HLA-DR5	TCR antagonism as antigen-specific process	5
HBc(18 – 27)	HLA-A2	Naturally occurring TCR antagonists: antagonism of cytolytic function	64

PCC = Pigeon cytochrome C; LCMV-GP = lymphocytic choriomeningitis virus-Gag protein; DP = double positive; MCC = moth cytochrome C; HA = influenza hemagglutinin; TT = tetanus toxoid; HBc = hepatitis B virus core; huColIV = human collagen IV.