Table 1.
Study participant characteristics for CAH and control youth
| CAH (n = 27) | Control (n = 35) | Group Difference, p-value | |
|---|---|---|---|
| Age, yr | 12.63 ± 3.35 | 13.03 ± 2.79 | CI: -2.0, 1.0; t (50.3) = -0.50; P = 0.62 |
| Biological sex, n | Male, 11; Female, 16 | Male, 15; Female, 20 | χ 2(1) = 0.00; P = 1 |
| Handedness, n | Right, 25; Left, 2 | Right, 30; Left, 5 | χ 2(1) = 1.97; P = 0.66 |
| Hispanic/Latino, % | 41 | 57 | χ 2(2) = 2.53; P = 0.28 |
| Race, % | White, 44; Black, 7; Asian, 4; Mixed race, 0; Not reported, 30 | White, 49; Black, 11; Asian, 6; Mixed race, 6; Not Reported, 20 | χ 2(4) = 2.09; P = 0.72 |
| Family income, n | < $49K, 11; > $49K, 14; Not reported, 2 | < $49K, 15; > $49K, 19; Not reported, 1 | χ 2(1) = 0.00; P = 1 |
| Maternal education, yr | 13.85 ± 3.32, n = 26 | 14.85 ± 3.47, n = 34 | CI: -2.8, 0.8; t (55.1) = 1.14; P = 0.26 |
| IQ | 100.22 ± 16.67 | 103.03 ± 15.30 | CI: -11.1, 5.5; t (53.5) = 0.68; P = 0.50 |
| BMI (kg/m2) | 27.12 ± 7.28 | 22.52 ± 5.87 | CI: 1.2, 8.0; t (49.2) = 2.67; P = 0.009 |
| BMI z-score | 1.61 ± 0.86 | 0.80 ± 0.95 | CI: 0.3, 1.3; t (58.5) = 3.51; P = 0.0009 |
| Tanner stage | 2.81 ± 1.64 | 3.31 ± 1.62 | CI: -1.3, 0.3; t (55.7) = 1.19; P = 0.24 |
| Bone age, yr | 13.43 ± 3.00 | 13.16 ± 2.77 | CI: -1.2, 1.8; t (53.7) = 0.36; P = 0.72 |
| Bone age SD | 1.44 ± 3.10 | 0.13 ± 0.60 | CI: 0.1, 2.5; t (27.5) = 2.16; P = 0.04 |
| Brain anomaly, n | Type 1 Chiari, 1; Arachnoid cyst, 2 | -- | |
| CAH form, n | SW, 25; SV, 2 | -- | |
| Newborn screen, n | Yes, 12; No, 15 | -- | |
| Fludrocortisone total daily dose (mg), n = 26 | 0.11 ± 0.04; range: 0.05–0.2 | -- | |
| Glucocorticoid total daily dose (mg/m2) | 16.5 ± 4.7; range: 7.9–29.6 | -- | |
| 17-OHP (ng/dL) [nmol/L] | 3,656 ± 4,694.8; range: 44–19,966 [110.8 ± 142.3; range: 1.3–605] | -- | |
| Plasma renin activity (ng/mL/hr and μg/L/hr) | 3.5 ± 2.9; range: 0.07–11.9 | -- | |
| Androstenedione (ng/dL) [nmol/L] | 150.5 ± 227.8; range: 10–881 [5.2 ± 8; range: 0.3–30.7] | -- | |
| Testosterone (ng/dL) [nmol/L] | 76.5 ± 155.3; range: 0.99–623 [2.7 ± 5.4; range: 0.03–21.6] | -- |
Mean ± SD