Table 3. Distribution of thyroid cancer cases and controls and corresponding odds ratios (OR) according to cigarette smoking and alcohol drinking.
Variable | Cases | Controls | Adjusted OR* (95% CI) | |
Men and women | ||||
Smoking history | Never | 292 | 271 | 1.00 (reference) |
Past | 17 | 11 | 1.39 (0.58-3.34) | |
Current | 53 | 80 | 0.46 (0.28-0.76) | |
≤15 cig./d | 24 | 30 | 0.53 (0.27-1.02) | |
16+ cig./d | 24 | 43 | 0.33 (0.16-0.69) | |
p trend = 0.001† | ||||
Alcohol-drinking | Never | 172 | 141 | 1.00 (reference) |
Non-daily | 155 | 167 | 0.75 (0.53-1.06) | |
Daily | 35 | 54 | 0.59 (0.35-1.01) | |
p trend = 0.032 | ||||
Men | ||||
Smoking history | Never | 14 | 9 | 1.00 (reference) |
Past | 7 | 7 | 0.68 (0.14-3.39) | |
Current | 36 | 41 | 0.57 (0.21-1.56) | |
≤15 cig./d | 10 | 9 | 0.46 (0.10-2.21) | |
16+ cig./d | 21 | 28 | 0.53 (0.18-1.58) | |
p trend = 0.28† | ||||
Alcohol-drinking | Never | 11 | 8 | 1.00 (reference) |
Non-daily | 37 | 25 | 1.18 (0.40-3.50) | |
Daily | 9 | 24 | 0.37 (0.10-1.40) | |
p trend = 0.032 | ||||
Women | ||||
Smoking history | Never | 278 | 262 | 1.00 (reference) |
Past | 10 | 4 | 2.12 (0.64-6.98) | |
Current | 17 | 39 | 0.38 (0.20-0.71) | |
≤15 cig./d | 14 | 21 | 0.54 (0.26-1.15) | |
16+ cig./d | 3 | 15 | 0.19 (0.06-0.68) | |
p trend = 0.002† | ||||
Alcohol-drinking | Never | 161 | 133 | 1.00 (reference) |
Non-daily | 118 | 142 | 0.67 (0.46-0.98) | |
Daily | 26 | 30 | 0.83 (0.44-1.55) | |
p trend = 0.14 |
* : Matched on city, age, sex, and radiation dose; adjusted for family history of cancer and past history of goiter or thyroid nodule; and mutually adjusted for smoking history (never, past, current) and alcohol drinking (never, non-daily, daily).
† : From never” to “current, ≤15 cigarettes/day” and “current, 16+ cigarettes/day”.
CI: confidence interval