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Adverse events
| Adverse Event | Total Population (n=60) |
Metolazone (n=20) |
Chlorothiazide (n=20) |
Tolvaptan (n=20) |
|---|---|---|---|---|
| SCr increase > 1mg/dl | 4 | 1 | 3 | 0 |
| Hypotension (SBP < 85mmHg) | 4 | 2 | 0 | 2 |
| Symptomatic Gout flare | 3 | 0 | 0 | 3 |
| Severe hypokalemia (Serum K+ < 3.0 mEq/L) | 1 | 1 | 0 | 0 |
| Myalgia/muscle cramping | 5 | 2 | 2 | 1 |
K+= serum potassium, SBP = systolic blood pressure, SCr = serum creatinine
