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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Hepatology. 2019 Dec 31;71(5):1732–1749. doi: 10.1002/hep.30927

Figure 1: Knockdown of β-catenin aggravates hepatobiliary injury in Mdr2 KO mice.

Figure 1:

(A) Schematic showing different delivery methods of β-catenin DsiRNA in Mdr2 KO mice. (B) qPCR shows significant decrease in Mdr2 gene expression in KO liver with and without β-catenin inhibition as compared to WT. (C) IF demonstrates almost complete reduction of β-catenin in hepatocytes in WT liver following its knockdown (200X). (D) Liver weight/body weight (LW/BW) ratio remains unchanged in KO/KD compared to Mdr2 KO. However, KO/KD had significantly higher serum ALP, ALT, AST, total bilirubin, and conjugated bilirubin levels compared to Mdr2 KO alone. **p<0.01; ****p<0.0001.