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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Hepatology. 2019 Dec 31;71(5):1732–1749. doi: 10.1002/hep.30927

Figure 3: Simultaneous loss of Mdr2 and β-catenin leads to impaired regenerative response in liver.

Figure 3:

IHC for PCNA shows increased proliferative response in Mdr2 KO mice, which was significantly reduced in KO/KD liver (50X; 100X inset). TUNEL staining revealed increased cell death in KO/KD liver compared to Mdr2 KO alone (50X; 100X inset). Quantification of PCNA and TUNEL staining further confirms the IHC interpretation. (B) IHC for β-catenin showed significantly reduced expression in KO/KD hepatocytes compared to WT or KO alone (100X; inset 200X). GS staining is reduced in Mdr2 KO as compared to WT and absent in KO/KD liver (50X; 100X inset). ****p<0.0001.