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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Hepatology. 2019 Dec 31;71(5):1732–1749. doi: 10.1002/hep.30927

Figure 6: Dysregulation of BA synthesis, metabolism and transport genes in KO/KD liver.

Figure 6:

(A) qPCR analysis shows decreased expression of several BA-regulated nuclear receptors in KO/KD liver. (B) Analysis of P450 expression shows that synthesis of BA is suppressed in KO/KD liver, while detoxification is increased. (C) BA uptake is suppressed, and basolateral efflux is increased, in KO/KD liver, as assessed by qPCR. (D) Tabular representation of the qPCR analysis shown in A, B, and C. (E) Levels of hepatic BA are unchanged between KO/KD and KO alone. *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.