TABLE 1.
The switch to a Small Colony Variant (SCV) by WCH-SK2 through continuous culture was associated with genetic events (SNPs) in global regulators of virulence.
| Agr | MgrA | ArlRS | SigB | |
| Extracellular components | ||||
| cap5A-P | + | + | + | + |
| icaABCD | + | + | ||
| ebh | ||||
| clfA | + | |||
| fnbA | − | + | ||
| fnbB | − | + | ||
| SpA | − | − | − | + |
| Leukocidins | ||||
| lukDE | + | + | − | − |
| lukSF | + | + | − | |
| lukM | + | − | ||
| Exotoxins | ||||
| hla | + | + | − | |
| hlb | + | + | − | |
| seb | + | + | − | |
| sea, seb, sec | + | |||
| etaA, etaB | + | |||
| tst-1 | + | |||
| Secretory proteases | ||||
| splA, splB, splC, splD | + | + | − | − |
| sspA | + | + | − | |
| sspBC | + | − | − | |
| nuc1 | + | + | − | |
| srtA | + | − | ||
| Autolysis | ||||
| lytM | − | + | ||
| lytN | − | − | ||
| lytSR | + | |||
| atl | − | |||
| cidA | − | |||
| lgrAB | + | + | − | |
| Metabolism | ||||
| Lactose metabolism | − | − | ||
| Urea metabolism | − | − | ||
| Arginine deaminase | − | − |
Shown are the change in expression of genes regulated in S. aureus pathogenesis through these global regulators. +, increased expression, −, decreased expression.