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. 2019 Jul 16;77(5):903–918. doi: 10.1007/s00018-019-03217-y

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — GO-term cluster analysis revealed an enrichment of mRNAs being downregulated and a target for miR-221/222 involved in cation channel complexes and T-tubule function. a Comparison of genes determined by whole transcriptome sequencing, being downregulated in mice with heart hypertrophy to target genes for miR-221/222 revealed an enrichment of genes involved in cardiac action potential (p = 5.30E − 8, g:Profiler, N = 6/group), with a threshold of p ≤ 0.01, FDR < 0.05. b Real-time qRT-PCR with heart samples from an additional cohort of mice w/o heart hypertrophy confirmed these findings (N = 30 animals/group, relative change compared to WT)