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. 2019 Jul 16;77(5):903–918. doi: 10.1007/s00018-019-03217-y

Fig. 6.

Fig. 6

Cacna1c mRNA correlates with the change in miR-221/222 expression in AII-treated animals. To test if the increase in miRNAs is correlated to the changes in Cacna1c and Kcnj5 expression, we performed real-time qRT-PCR in the two mouse models with pharmacologically induced heart hypertrophy. While in AII-treated animals, Cacna1c was downregulated, there was no change in Cacna1c in isoprenaline-treated animals (a) AII: N = 12–15 animals/group, b isoprenaline: 5–6 animals/group (relative change compared to control)