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. 2020 Mar 5;3:104. doi: 10.1038/s42003-020-0812-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Regional association plots of the entire mtDNA illustrating the genotype–phenotype associations identified by the mitochondrial PheWAS in the Japanese population (n = 147,310). Y-axes represent –log₁₀(P) of the associations of the variants and x-axes represent the base pair positions in mtDNA. An upper horizontal bar in each plot represents the study-wide significance threshold of P = 2.5 × 10⁻⁶, considering multiple comparisons of both the numbers of the variants and phenotypes. A lower horizontal bar in each plot represent the study-wide significance threshold of P = 2.4 × 10⁻⁴, considering multiple comparisons of the number of the variants. Mitochondrial gene positions are indicated in the bottom panel.