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A working model illustrating the effect of maternal VDD on MetS in their offspring. A working model depicting how maternal VDD effects offspring metabolic function was shown. Maternal VDD leads to the inhibition of Nrf2/CBR1 pathway both in mother and their offspring. Further, the depression of the Nrf2/CBR1 pathway in both the mother and her offspring is the main cause of oxidative stress leading to MetS.
