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. 2020 Feb 28;11:363. doi: 10.3389/fimmu.2020.00363

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Copyright © 2020 Jaiswal, Makhija, Stahr, Sandey, Suryawanshi, Saxena, Dagur, McCoy, Levine and Mishra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adam 17 up-regulation in obesity affects DC-restricted progenitors. (A) Histogram and (B) representative FACS plots showing basal and PMA-stimulated levels of phosphorylated p38 and (C) mean percentages of EdU (5-ethynyl-2′-deoxyuridine) showing proliferation of CDPs treated with selective Adam 17 inhibitor. BM hematopoietic stem cells were isolated from HFD mice and cultured overnight in presence of Adam 17 inhibitor TMI 1 (50 μM). Phosphorylation and proliferation analyses showing on gated LSK⁺ CD115⁺ Flt3⁺ cells. (D) qRT-PCR analyses for S-G2/M-cyclins (B2, G1, and F) gene expression in cultured cells isolated from HFD mice. Data expressed as mean ± s.e.m. n = 4. Student's t-test *P < 0.05. (E) Schematic representation of proposed Adam 17-p38 MAPK signaling in DC-restricted progenitors in obesity-associated airway inflammation.