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Pathogen-derived peptide ligands bind to the InsB4 TCR. (A) Optimised pMHC tetramer staining of the InsB4 T-cell clone with HLA A2-HLVEALYLV (insulin), HLA A2-MLLENGLLA (H. pylori) and HLA A2-MIVENVPLL (C. albicans) epitopes. (B) SPR binding data of the interaction between the InsB4 TCR and HLA A2-MIVENVPLL and HLA A2-MLLENGLLA. Binding with the index HLA A2-HLVEALYLV peptide was too weak to measure.
