Table 2.

Blood Parameter Changes

	Day 19		Day 43
	Vehicle ± SD	125 mg/kg/day ± SD	Vehicle ± SD	125 mg/kg/day ± SD
Hematologic Parameter
NeutroHephil	0.95 ± 0.443* F	0.37 ± 0.08 F	1.81 ± 0.567 M	0.76 ± 0.057 M
Reticulocytes	2.88 ± 0.997** F	1.46 ± 0.219 F	2.39 ± 0.656 F	1.39 ± 0.354 F
Monocytes			0.55 ± 0.186 M	0.14 ± 0.028 M
LUC			$\frac{0.19\pm 0.07\text{ M}}{0.11\pm 0.05\text{ F}}$	$\frac{0.08\pm 0.00\text{ M}}{0.04\pm 0.00\text{ F}}$
Eosinophils	0.08 ± 0.032	0.14 ± 0.045
Biochemistry Parameter
Creatinine	$\frac{22.32\pm 0.980\text{ M}}{26.62\pm 0.972\text{ F}}$	$\frac{35.58\pm 5.109\ast \text{ M}}{31.26\pm 1.547\ast \ast \text{ F}}$	28.40 ± 1.563 M	35.58 ± 1.450 M
Urea	$\frac{4.5\pm 0.68\text{ M}}{4.9\pm 0.40\text{ F}}$	$\frac{7.2\pm 1.77\ast \text{ M}}{6.4\pm 0.61\text{ F}}$	$\frac{4.5\pm 0.52\text{ M}}{4.7\pm 0.38\text{ F}}$	$\frac{6.9\pm 0.71\text{ M}}{7.1\pm 1.27\text{ F}}$
Glucose	5.76 ± 0.534 M	7.75 ± 1.041** M	$\frac{6.16\pm 0.855\text{M}}{6.42\pm 0.255\text{ F}}$	$\frac{8.74\pm 0.184\text{M}}{8.69\pm 1.57\text{ F}}$
Triglyceride	0.51 ± 0.151 M	0.21 ± 0.037* M	0.82 ± 0.339 M	0.18 ± 0.071 M
ALAT	39 ± 4.3 M	59 ± 6.4* M	47 ± 10.2 M	34 ± 3.5 M

Blood parameter changes were observed at the end of the treatment period (day 19, n = 5/sex/group) and at the end of the recovery period (day 43, n = 3/sex/group) as measured in the animal group treated with 125 mg/kg/day of LNA-i-miR-221 or in the control (vehicle) group. M, male; F, female. *p < 0.01, **p < 0.05.