Fig. 6.

C. sakazakii–stimulated mammalian mammary gland epithelium induced apoptosis via activating AIM2 pathway and excessive ER stress response. E. sakazakii was isolated from bovine mastitis milk sample, which was used to infected mice and BMECs. E. sakazakii–infected mammary gland epithelium activated AIM2 inflammasome and induced excessive endoplasmic reticulum stress response. However, there has been no evidence to support the relationship between AIM2 inflammasome activation and endoplasmic reticulum stress. Finally, apoptosis occurred in mammary epithelial cells