Table 2.
Minimal inhibitory concentration values, geometric mean, and essential agreement between Etest and CLSI broth microdilution of 16 clinical Pucciniomycotina red-yeasts isolates from patients with fungemia to azoles (Voriconazole, Itraconazole and Posaconazole)
| Species (number of isolates) | Method | Voriconazole (μg/ml) | Itraconazole (μg/ml) | Posaconazole (μg/ml) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC range | MIC50/MIC90 | GM | %EA | MIC range | MIC50/MIC90 | GM | %EA | MIC range | MIC50/MIC90 | GM | %EA | ||
| Rhodotorula mucilaginosa (12) | CLSI | 2-8 | 4/8 | 3.77 | 2-8 | 4/8 | 3.36 | 2-8 | 4/8 | 5.04 | |||
| Etest | 0.5-32 | 2/16 | 1.97 | 100 | 0.75->32 | 8/32 | 7.65 | 61.5 | 0.5->32 | 16/32 | 8.25 | 76.9 | |
| Rhodotorula dairenensis (1) | CLSI | 1 | - | - | 0.12 | - | - | 2 | - | - | |||
| Etest | 2 | - | - | 100 | 0.75 | - | - | 0 | 0.75 | - | - | 100 | |
| Rhodotorula toruloides (2) | CLSI | 0.25-2 | - | 0.70 | 0.12-2 | - | 0.49 | 0.25-0.5 | - | 0.35 | |||
| Etest | 1.5 | - | 1.5 | 100 | 0.125-3 | - | 0.61 | 100 | 0.125->32 | - | 2 | 50 | |
| Cystobasidium minutum (1) | CLSI | 2 | - | - | 0.25 | - | - | 0.5 | - | - | |||
| Etest | 1.5 | - | - | 100 | 1.5 | - | - | 100 | >32 | - | - | 0 | |
MIC50/MIC90 minimal inhibitory concentration of the antifungal able to inhibit the growth of 50 and 90% of fungal isolates, respectively, GM geometric mean of the minimal inhibitory concentrations values, EA essential agreement