Figure 4.

Proportion of Causal SNPs Selected under Various Conditions

Proportion of selected SNPs which were causal or regional, selected by the forward selection algorithm under various simulated conditions. Proportion of causal SNPs (y axis) was calculated as: (number of selected causal SNPs + number of selected regional SNPs) / (number of true, unobserved, causal SNPs). True, unobserved, local variances were pre-specified at 0.1, 0.2, and 0.3 (x axis) as determined by 1, 2, 3, 5 or 10 causal SNPs. (A and B) illustrate simulated conditions with no directional condition, while (C and D) restrict local effects to be greater than 0. (A and C) illustrate simulated conditions with no global effect, and (B and D) each have a pre-specified global effect.