Figure 6.

Manhattan Plot of Admixture Mapping of C-Peptide Protein

Mirror Manhattan plot of the association between local Asian ancestry (top) and local African ancestry (bottom) with C-peptide, made using the additive estimated model as determined by the forward selection algorithm. In other words, each point represents the association between a single local component and C-peptide, after residualizing for age and sex, adjusted for global African and Asian ancestry and the two significant SNPs falling below (for African) or above (for Asian) the selected threshold (shown in red), based on experiment-wide adjusted p value (1.13 × 10⁻⁶). Negative log 10 p values are plotted against each local component’s respective position on each chromosome. The blue line corresponds to nominal significance of p = 1 × 10⁻⁴. Local components in LD (r² > 0.8) with any SNP within 300KB of the gene encoding c-peptide protein are shown in green.