Table 1.
Summary of Biomarkers with Significant Proportion of Variation Explained by Local Ancestry in Using VC Analysis (p < 0.05/237)
| Biomarker | Both | African | Asian | |||
|---|---|---|---|---|---|---|
| Proportion Explained and p Value | Proportion Explained(95% CI) | p Value | Proportion Explained(95% CI) | p Value | Proportion Explained(95% CI) | p Value |
| C-peptide | 0.24 (0.16, 0.32) | 1.6 × 10−11 | 0.22 (0.15, 0.29) | 9.9 × 10−12 | 0.02 (−0.02, 0.06) | 0.13 |
| eotaxin-3 | 0.22 (0.14, 0.29) | 5.0 × 10−10 | 0.03 (0.00, 0.07) | 0.02 | 0.19 (0.12, 0.25) | 8.1 × 10−9 |
| clusterin | 0.18 (0.11, 0.25) | 2.2 × 10−8 | 0.16 (0.10, 0.22) | 1.6 × 10−8 | 0.02 (−0.01, 0.06) | 0.10 |
| fatty acid-binding protein liver | 0.13 (0.07, 0.19) | 2.4 × 10−6 | 0.11 (0.06, 0.16) | 1.3 × 10−6 | 0.02 (−0.02, 0.06) | 0.13 |
| intercellular adhesion molecule-1 | 0.14 (0.08, 0.21) | 3.1 × 10−6 | 0.08 (0.03, 0.13) | 0.00018 | 0.06 (0.01, 0.11) | 0.0042 |
| apolipoprotein E | 0.14 (0.07, 0.20) | 4.0 × 10−6 | 0.10 (0.05, 0.15) | 9.4 × 10−6 | 0.03 (−0.01, 0.08) | 0.05 |
| Fas ligand | 0.14 (0.08, 0.20) | 4.6 × 10−6 | 0.08 (0.03, 0.12) | 0.00030 | 0.06 (0.02, 0.11) | 0.0037 |
| alpha-2 macroglobulin | 0.12 (0.06, 0.18) | 1.2 × 10−5 | 0.03 (0.00, 0.06) | 0.038 | 0.09 (0.04, 0.14) | 0.00010 |
| apolipoprotein A-IV | 0.12 (0.06, 0.18) | 3.2 × 10−5 | 0.07 (0.03, 0.12) | 0.00039 | 0.05 (0.00, 0.09) | 0.017 |
| interleukin-2 | 0.12 (0.06, 0.18) | 4.0 × 10−5 | 0.11 (0.06, 0.16) | 1.1 × 10−5 | 0.02 (−0.02, 0.06) | 0.22 |
| paraoxanase-1 | 0.11 (0.05, 0.17) | 8.7 × 10−5 | 0.07 (0.03, 0.12) | 0.00028 | 0.04 (−0.01, 0.08) | 0.048 |
Biomarkers were residualized for age and sex.
CI = confidence interval